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She was fluent in several languages, including Tamil, Telugu, Kannada, Hindi, Malayalam and English.[32] She spoke with actress Saroja Devi in Kannada regularly as they were close friends and would talk to each other only in Kannada. She often conversed with Karnataka Chief ministers in Kannada. Basavaraj Bommai, the former irrigation minister and present chief minister of Karnataka said, \"I was astonished by her Kannada slang and fluency.\"[33][34]

In August 2018, producer Vishnu Vardhan Induri of Vibri Media announced that he was working on a biopic of Jayalalithaa, and that A. L. Vijay would direct the project.[308] The team announced that pre-production work and research was ongoing and that the film would focus on the personal life of the politician, showing her vulnerable side. Actresses including Nayanthara and Vidya Balan were initially approached by Vijay to star in the lead role, while Sai Pallavi was considered for the supporting role of V. K. Sasikala. Titled Thalaivii (2021), the film began its shoot after a long pre-production phase in November 2019 with Kangana Ranaut signed to play the lead role.[309][310][311] The Movie Thalaivii was released on 10 September 2021.[312] Within a day of Induri's announcement of making a film, director Priyadarshini announced that she had also been working for four months on the pre-production of a biopic, which would be launched in September 2018. Priyadarshini suggested that she had four scripts ready, with each focusing on different aspects of Jayalalithaa's life, and that the narration would be balanced by showing both her positive and negative sides.[313][311] Titled The Iron Lady, Nithya Menen was signed on to play the lead role, while Aishwarya Rajesh and Varalaxmi Sarathkumar were in talks for a supporting role for the character of Sasikala.[314][315][316]

On 14 December 2019, Another biopic named Queen has been released as a web-series by Gautham Vasudev Menon became the fourth such announcement of a related project in August 2018.[317] Production on the series progressed quietly throughout late 2018, with Ramya Krishnan selected to play Jayalalithaa, and Indrajith and Vamsi Krishna portraying M. G. Ramchandran and Sobhan Babu respectively.[318][319] In October 2018, Sasikala's nephew Jeyanandh Dhivakaran announced a further biopic on Jayalalithaa, which would focus more on her relationship with Sasikala and M. Natarajan. Director Linguswamy was signed on to the project, and began pre-production work by meeting close aides and politicians of Jayalalithaa.[320] In April 2019, director Jegadeswara Reddy announced that he was set to make a film titled Sasilalithaa, which would showcase the relationship between Jayalalithaa and Sasikala. A first look poster was launched, with Reddy announcing that he would enter talks with Kajol and Amala Paul to play the lead roles.[321]

Jayalalithaa also appeared in an episode of Rendezvous with Simi Garewal, an informal chat-show hosted by Indian actress Simi Garewal, where she talked about her personal life and acting/political career.[322]

Genomics has proved its relevance to all aspects of biology and medicine. It is now common to talk about sequencing entire populations and countries, resolving organs and individuals at the single-cell level, and developing treatments guided by genomic data. We are now able to edit genomes at will, synthesize entire chromosomes, and perform big data experiments in silico without ever touching a pipette. Importantly, while much has been done, much remains to be discovered as our knowledge of the human genome is far from complete. We possess only a rudimentary understanding of the non-coding regulatory genome, and polygenic risk scores hold the promise for dissecting genetic contributions to complex disease. New technology platforms, such as epigenetics and transcriptomes deployed at scale, will be undoubtedly essential to further understand the elusive connections between genotype and phenotype, a fundamental underpinning of genetics. Besides humans, understanding genomic variation in non-human species, including microbiomes, flora and fauna will further improve our mapping of the limits of biological variation, with impact in the emerging areas of food, nutrition, and health. In the clinic, genomic medicine raises the possibility of improving early diagnosis and prevention - however, we also need to appreciate the potential risks of genomic misuse, and the need to interact with community stakeholders to develop ethical social-legal frameworks respecting individual privacy yet enabling responsible data sharing for research and discovery. Our ultimate vision is for genomics to touch the lives of every Singaporean, in one way or another.

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